解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVE:To examine urinary levels of enterolactone and enterodiol, intestinal microbial metabolites of dietary lignans, in relation to type 2 diabetes (T2D) risk. RESEARCH DESIGN AND METHODS:Urinary concentrations of the lignan metabolites were assayed by liquid chromatography-mass spectrometry among 1,107 T2D and 1...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc13-2513
更新日期:2014-01-01 00:00:00
abstract::OBJECTIVE We tested whether average monthly glycemic burden (AMGB), a marker of hyperglycemia that is a function of the extent and duration that A1C exceeded 7%, indicated greater risk of cardiovascular disease (CVD) than traditional A1C measures. RESEARCH DESIGN AND METHODS Using a case-control design, we studied 2,4...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-1300
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To describe market trends for antidiabetic drugs, focusing on newly approved drugs, concomitant use of antidiabetic drugs, and effects of safety concerns and access restrictions on thiazolidinedione use. RESEARCH DESIGN AND METHODS:Nationally projected data on antidiabetic prescriptions for adults dispensed ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-2289
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To identify the clinical and genetic factors that explain why the rate of diabetes progression is highly variable between individuals following diagnosis of type 2 diabetes. RESEARCH DESIGN AND METHODS:We studied 5,250 patients with type 2 diabetes using comprehensive electronic medical records in Tayside, S...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-1995
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:The objectives of this study were to compare early predictive marker of the metabolic syndrome with proopiomelanocortin (POMC) methylation status and to determine the association among birth weight, ponderal index, and cord blood methylation status. RESEARCH DESIGN AND METHODS:We collected pregnancy outcome ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-1012
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Diabetes has held steady as the seventh leading cause of death in the U.S. since 2006. While aggregated data provide insights into how the country as a whole, or even as states, is faring with respect to diabetes mortality, disaggregation provides data that may facilitate targeted interventions and community ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0988
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To evaluate safety and efficacy of DiaPep277 in preserving β-cell function in type 1 diabetic patients. RESEARCH DESIGN AND METHODS:DIA-AID 1 is a multinational, phase 3, balanced-randomized, double-blind, placebo-controlled, parallel-group clinical study. Newly diagnosed patients (N = 457, aged 16-45 years)...
journal_title:Diabetes care
pub_type: 杂志文章,收录出版
doi:10.2337/dc13-1391
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Type 1 diabetes is associated with a markedly increased risk of stroke, but only a few studies on the incidence of stroke in type 1 diabetes exist. Therefore, we assessed the incidence of stroke in patients with type 1 diabetes and studied the impact of diabetic nephropathy (DN) and severe diabetic retinopath...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究
doi:10.2337/dc13-0669
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To assess effectiveness of inpatient hybrid closed-loop control (HCLC) followed by outpatient sensor-augmented pump (SAP) therapy initiated within 7 days of diagnosis of type 1 diabetes on the preservation of β-cell function at 1 year. RESEARCH DESIGN AND METHODS:Sixty-eight individuals (mean age 13.3 ± 5.7 ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc13-1074
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To assess prospectively the effect of benchmarking on quality of primary care for patients with type 2 diabetes by using three major modifiable cardiovascular risk factors as critical quality indicators. RESEARCH DESIGN AND METHODS:Primary care physicians treating patients with type 2 diabetes in six Europea...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc12-1853
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Use of automated bolus advisors is associated with improved glycemic control in patients treated with insulin pump therapy. We conducted a study to assess the impact of using an insulin bolus advisor embedded in a blood glucose (BG) meter on glycemic control and treatment satisfaction in patients treated with...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc13-0251
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Comparative effectiveness research methods are used to compare the effect of four distinct glucose-control strategies on subsequent myocardial infarction and nephropathy in type 2 diabetes. RESEARCH DESIGN AND METHODS:A total of 58,000 adults with type 2 diabetes and A1C <7% (53 mmol/mol) while taking two or...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2675
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:High birth weight is a risk factor for neonatal complications. It is not known if the risk differs with body proportionality. The primary aim of this study was to determine the risk of adverse pregnancy outcome in relation to body proportionality in large-for-gestational-age (LGA) infants stratified by matern...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0899
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Plasma copeptin, a surrogate for vasopressin, was associated with albuminuria in population-based studies. These associations are consistent with the effect of vasopressin on albuminuria observed in humans and rodents. The objective of this study was to determine whether plasma copeptin is an independent mark...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0683
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To assess the association of hypoglycemic treatment regimens with cardiovascular adverse events and mortality in a large population of type 2 diabetic patients at increased cardiovascular risk. RESEARCH DESIGN AND METHODS:This analysis included 8,192 overweight patients with type 2 diabetes from the Sibutram...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc13-0027
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:The structural basis of normoalbuminuric renal insufficiency in patients with type 2 diabetes remains to be elucidated. We compared renal biopsy findings in patients with type 2 diabetes and estimated glomerular filtration rate (eGFR) and measured GFR of <60 mL/min/1.73 m2, associated with either normo-, micr...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2572
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Mild demyelination may contribute more to the pathophysiology of nerve fiber injury in diabetic sensorimotor polyneuropathy (DSP) than previously thought. We investigated the clinical and electrodiagnostic classifications of nerve injury in diabetic patients to detect evidence of conduction slowing in DSP. R...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0746
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Preclinical data suggest that linagliptin, a dipeptidyl peptidase-4 inhibitor, may lower urinary albumin excretion. The ability of linagliptin to lower albuminuria on top of renin-angiotensin-aldosterone system (RAAS) inhibition in humans was analyzed by pooling data from four similarly designed, 24-week, ran...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc13-0323
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD). Obstructive sleep apnea (OSA) is common in type 2 diabetes and increases oxidative stress. Hence, OSA could promote the development and progression of DN. RESEARCH DESIGN AND METHODS:This was a cohort study in adults with type 2 ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0450
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Individuals with impaired glucose tolerance (IGT) are at high risk for developing type 2 diabetes mellitus (T2DM). We examined which characteristics at baseline predicted the development of T2DM versus maintenance of IGT or conversion to normal glucose tolerance. RESEARCH DESIGN AND METHODS:We studied 228 su...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0520
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:To assess the success and baseline predictors of maintaining glycemic control for up to 5 years of therapy using basal insulin glargine or standard glycemic care in people with dysglycemia treated with zero or one oral glucose-lowering agents. RESEARCH DESIGN AND METHODS:Data from 12,537 participants in the ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc12-2238
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:This study used qualitative interviews with black and Latino participants with diabetes to further understanding about types of foods eaten, food preparation, sources of foods and meals, communication with providers, and effects of race and ethnicity on eating in this population. RESEARCH DESIGN AND METHODS:...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1632
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:Blood pressure control can reduce the risk of coronary heart disease (CHD) among diabetic patients; however, it is not known whether the lowest risk of CHD is among diabetic patients with the lowest blood pressure level. RESEARCH DESIGN AND METHODS:We performed a prospective cohort study (2000-2009) on diabe...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0189
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2671
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:Acute hypoglycemia impairs cognitive function in several domains. Executive cognitive function governs organization of thoughts, prioritization of tasks, and time management. This study examined the effect of acute hypoglycemia on executive function in adults with and without diabetes. RESEARCH DESIGN AND ME...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc13-0194
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To examine β-cell function across a spectrum of glycemia among Asian Indians, a population experiencing type 2 diabetes development at young ages despite low BMI. RESEARCH DESIGN AND METHODS:One-thousand two-hundred sixty-four individuals without known diabetes in the Diabetes Community Lifestyle Improvement...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2290
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To examine the independent and combined association of isometric muscle strength of the abdomen and back and cardiorespiratory fitness (CRF) in youth with indices of glucose metabolism in young adulthood among boys and girls from the European Youth Heart Study. RESEARCH DESIGN AND METHODS:We used data from a...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2252
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Many non-European ethnic groups have an increased risk for diabetes; however, the published literature demonstrates considerable uncertainty about the rates of diabetes complications among minority populations. The objective of this study was to determine the risks of cardiovascular complications and of morta...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2105
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:This study assessed the ability to distinguish between type 1 diabetes-affected individuals and their unaffected relatives using HLA and single nucleotide polymorphism (SNP) genotypes. RESEARCH DESIGN AND METHODS:Eight models, ranging from only the high-risk DR3/DR4 genotype to all significantly associated H...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc12-2284
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Type 1 diabetes mellitus causes increased carotid intima-media thickness (IMT) in adults. We evaluated IMT in young subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS:Participants with type 1 diabetes (N = 402) were matched to controls (N = 206) by age, sex, and race or ethnicity. Anthropometric and ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2024
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Little is known about the psychosocial challenges of adults living with type 1 diabetes or its impact on partner relationships. This qualitative study was undertaken to gain better understanding of these issues. RESEARCH DESIGN AND METHODS:Four focus groups were held, two with adult type 1 diabetic patients ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1718
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:The current study aimed to determine in the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications cohort whether or not abnormal levels of markers of inflammation and endothelial dysfunction measured in samples collected at DCCT baseline were able to predict ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc12-2521
更新日期:2013-08-01 00:00:00
abstract::Significant data suggest that overt hyperglycemia, either observed with or without a prior diagnosis of diabetes, contributes to an increase in mortality and morbidity in hospitalized patients. In this regard, goal-directed insulin therapy has remained as the standard of care for achieving and maintaining glycemic con...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2060
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:The effect of therapeutic strategies on cardiovascular (CV) disease can be evaluated by monitoring changes in CV risk biomarkers. This study investigated the effect of a structured self-monitoring of blood glucose (SMBG) protocol and the resulting improvements in glycemic control on changes in high-sensitivit...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1711
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Best-practice diabetes care can reduce the burden of diabetes and associated health care costs. But this requires access to a multidisciplinary team with the right skill mix. We applied a needs-driven evidence-based health workforce model to describe the primary care team required to support best-practice dia...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1793
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Dietary protein is an important modulator of glucose metabolism. However, studies regarding the association between dietary protein intake and gestational diabetes mellitus (GDM) risk are sparse. This study was to examine the association. RESEARCH DESIGN AND METHODS:Our study included 21,457 singleton pregna...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-2018
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Ethnic differences in type 2 diabetes risk between South Asians and white Europeans originate before adult life and are not fully explained by higher adiposity levels in South Asians. Although metabolic sensitivity to adiposity may differ between ethnic groups, this has been little studied in childhood. We ha...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1726
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:Malabsorptive bariatric surgery (biliopancreatic diversion and biliointestinal bypass [BIBP]) reduces serum cholesterol levels more than restrictive surgery (adjustable gastric banding [AGB]), and this is thought to be due to greater weight loss. Our aim was to evaluate the changes of cholesterol metabolism i...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1737
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the accuracy of the UK Prospective Diabetes Study Outcomes Model (UKPDS-OM) in predicting clinical outcomes during the UKPDS posttrial monitoring (PTM) period. RESEARCH DESIGN AND METHODS:At trial end in 1997, the 4,031 surviving UKPDS patients, of the 5,102 originally enrolled in the study, retu...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1120
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:The risk of cardiovascular death before the age of 40 is 20-fold higher in patients with type 1 diabetes mellitus (T1DM). Endothelial progenitor cells (EPCs) predict cardiovascular morbidity and mortality in patients without diabetes. We hypothesized that EPCs are modified in children with T1DM and are relate...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc12-1206
更新日期:2013-06-01 00:00:00